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Table 1 Buprenorphine low dose overlap initiation (LDOI) schedule

From: Low-dose overlap initiation with split tablets of buprenorphine in intubated intensive care unit patients with opioid use disorder

Day

Daily buprenorphine dosing sublingual (mg)

Number of tablet(s) per dose*

Total Daily Dose of buprenorphine (mg)

Pre-existing Opioid Agonist (e.g. fentanyl infusion)

1

0.5 mg QD

One-quarter tab

0.5 mg

Continue

2

0.5 mg BID

One-quarter tab

1 mg

Continue

3

1 mg BID

One-half tab

2 mg

Continue

4

2 mg BID

1 tab

4 mg

Continue

5

4 mg BID

1 tab

8 mg

Continue

6

4 mg TID

1 tab

12 mg

Continue

7+

8 mg BID

2 tabs+

16 mg

Stop/Taper

  1. QD = every day, BID = twice daily, TID = three times daily
  2. * buprenorphine tablets available in 2 mg or 4 mg dosage
  3. +dose may be further increased based on individual patient circumstances
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Harm Reduction Journal

ISSN: 1477-7517