Fig. 3

Potential life problems change over time for given opioid consumption frequency levels per 28-day period. Effect plot was derived from the generalized linear mixed model. Opioid use was self-reported every two weeks using the Timeline Follow-Back (TLFB) questionnaire. ASI change represents the change in ASI score for each domain from baseline (week 0) to the end of the study (week 24). ASI = Addiction severity index