Fig. 4

Opioid use frequency thresholds required for improvement in potential life problems. Maximum number of days of opioid use per 28-day period associated with a positive trend in potential life problems was identified for each ASI domain based on effect plots (Fig. 3, S1) derived from the generalized linear mixed model. A positive trend in potential life problems was defined by a slope of ASI score above zero in the effect plots. The family status ASI domain has not been included because it tended to improve no matter the frequency of opioid use. ASI = Addiction severity index