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Table 10 Estimated RRs for use of ECIGs. Results of sensitivity analyses

From: Estimating lung cancer risk from e-cigarettes and heated tobacco products: applications of a tool based on biomarkers of exposure and of potential harm

Sensitivity analysis

Description

N

Estimated RR (95% CI)

-

Original estimate

30

1.88 (1.60–2.22)

1

At least four ratio estimates

30

1.88 (1.60–2.32)

 

At least six ratio estimates

15

2.18 (1.83–2.61)

2

Restricting attention to biomarkers with any slope

86

13.03 (11.91–14.25)

 

Restricting attention to biomarkers with slope p < 0.05

43

11.63 (8.79–15.40)

 

Restricting attention to biomarkers with slope p < 0.001

17

2.00 (1.67–2.39)

3

Restricting attention to studies with well-defined groups

22

1.98 (1.46–2.70)

 

(a) and to biomarkers with any slope

72

2.06 (1.74–2.23)

 

(b) and to biomarkers with slope p < 0.05

35

1.92 (1.54–2.39)

 

(c) and to biomarkers with slope p < 0.001

4

2.07 (0.80–5.36)

4

Varying the RR for snuff/snus from 0.80 to 1.00

27

1.92 (1.61–2.29)