Sensitivity analysis | Description | N | Estimated RR (95% CI) |
---|---|---|---|
- | Original estimate | 30 | 1.88 (1.60–2.22) |
1 | At least four ratio estimates | 30 | 1.88 (1.60–2.32) |
 | At least six ratio estimates | 15 | 2.18 (1.83–2.61) |
2 | Restricting attention to biomarkers with any slope | 86 | 13.03 (11.91–14.25) |
 | Restricting attention to biomarkers with slope p < 0.05 | 43 | 11.63 (8.79–15.40) |
 | Restricting attention to biomarkers with slope p < 0.001 | 17 | 2.00 (1.67–2.39) |
3 | Restricting attention to studies with well-defined groups | 22 | 1.98 (1.46–2.70) |
 | (a) and to biomarkers with any slope | 72 | 2.06 (1.74–2.23) |
 | (b) and to biomarkers with slope p < 0.05 | 35 | 1.92 (1.54–2.39) |
 | (c) and to biomarkers with slope p < 0.001 | 4 | 2.07 (0.80–5.36) |
4 | Varying the RR for snuff/snus from 0.80 to 1.00 | 27 | 1.92 (1.61–2.29) |