Table 3 Mean and 95% confidence intervals of cardiometabolic measurements for participants during snus cessation

Body weight (kg)

Run-in to Week 4

32

82.7 (77.1–88.2)

84.5 (79.0–90.0)

1.8 (1.4 to 2.3)

 < .001

Week 4 to Week 12

29

84.5 (78.6–90.4)

84.7 (78.8–90.6)

0.2 (− 0.4 to 0.8)

.555

Run-in to Week 12

31

83.5 (77.7–89.3)

85.3 (79.6–91.0)

1.8 (1.1 to 2.4)

 < .001

Plasma total cholesterol (mmol/L)

Run-in to Week 4

33

4.79 (4.46–5.12)

5.01 (4.70–5.32)

0.22 (0.05 to 0.38)

.010

Week 4 to Week 12

30

4.90 (4.61–5.20)

4.87 (4.54–5.19)

− 0.04 (− 0.22 to 0.15)

.688

Run-in to Week 12

31

4.72 (4.39–5.05)

4.89 (4.57–5.21)

0.17 (− 0.03 to 0.37)

.086

Plasma triglycerides (mmol/L)

Run-in to Week 4

33

1.03 (0.91–1.15)

1.09 (0.93–1.25)

0.06 (− 0.06 to 0.18)

.288

Week 4 to Week 12

30

1.06 (0.91–1.22)

1.03 (0.81–1.24)

− 0.04 (− 0.17 to 0.10)

.587

Run-in to Week 12

31

1.12 (0.90–1.33)

1.09 (0.85–1.34)

− 0.03 (− 0.18 to 0.13)

.732

Plasma LDL (mmol/L)

Run-in to Week 4

33

2.90 (2.63–3.17)

3.04 (2.79–3.28)

0.13 (− 0.01 to 0.27)

.064

Week 4 to Week 12

30

3.01 (2.74–3.28)

2.99 (2.70–3.28)

− 0.02 (− 0.20 to 0.16)

.819

Run-in to Week 12

31

2.85 (2.58–3.13)

3.00 (2.72–3.28)

0.15 (− 0.04 to 0.33)

.124

Plasma HDL (mmol/L)

Run-in to Week 4

33

1.41 (1.26–1.56)

1.47 (1.31–1.63)

0.06 (0.02 to 0.09)

.002

Week 4 to Week 12

30

1.40 (1.26–1.55)

1.39 (1.23–1.54)

− 0.02 (− 0.07 to 0.03)

.452

Run-in to Week 12

31

1.34 (1.21–1.48)

1.37 (1.22–1.52)

0.03 (− 0.02 to 0.09)

.236

Plasma non-HDL (mmol/L)

Run-in to Week 4

33

3.37 (3.07–3.67)

3.54 (3.27–3.81)

0.17 (0.02 to 0.32)

.025

Week 4 to Week 12

30

3.50 (3.21–3.79)

3.47 (3.16–3.77)

− 0.03 (− 0.21 to 0.14)

.702

Run-in to Week 12

31

3.36 (3.04–3.69)

3.50 (3.20–3.81)

0.14 (− 0.04 to 0.32)

.124

Plasma glucose (mmol/L)

Run-in to Week 4

33

5.23 (5.07–5.39)

5.24 (5.09–5.39)

0.01 (− 0.11 to 0.13)

.840

Week 4 to Week 12

30

5.23 (5.07–5.39)

5.31 (5.11–5.51)

0.08 (− 0.02 to 0.18)

.104

Run-in to Week 12

31

5.24 (5.06–5.41)

5.31 (5.12–5.50)

0.08 (− 0.06 to 0.21)

.255

Blood HbA1c (mmol/mol)

Run-in to Week 4

33

34.9 (33.9–36.0)

34.9 (33.8–36.0)

0.0 (− 0.6 to 0.6)

.919

Week 4 to Week 12

30

35.0 (33.8–36.2)

35.6 (34.4–36.9)

0.6 (− 0.1 to 1.5)

.097

Run-in to Week 12

31

35.0 (33.9–36.1)

35.7 (34.5–37.0)

0.7 (0.0 to 1.6)

.048

Plasma insulin (mIE/L)

Run-in to Week 4

33

8.06 (6.56–9.55)

8.58 (6.84–10.32)

0.52 (− 0.59 to 1.63)

.343

Week 4 to Week 12

30

8.84 (6.95–10.72)

8.60 (6.58–10.63)

− 0.23 (− 1.60 to 1.14)

.730

Run-in to Week 12

31

8.69 (6.95–10.44)

8.81 (6.81–10.81)

0.12 (− 1.28 to 1.51)

.866

Plasma hsCRP (mg/L)

Run-in to Week 4

32

1.02 (0.52–1.51)

1.47 (0.92–2.02)

0.46 (0.03 to 0.88)

.036

Week 4 to Week 12

29

1.52 (0.92–2.13)

1.33 (0.77–1.89)

− 0.19 (− 0.43 to 0.05)

.116

Run-in to Week 12

31

1.16 (0.64–1.69)

1.41 (0.88–1.95)

0.25 (− 0.18 to 0.68)

.245