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  1. Impacts of the toxic unregulated drug supply are experienced across all geographic regions in Canada, with high rates of fatal and non-fatal overdoses nation-wide. In British Columbia, rates of overdose fatali...

    Authors: Abby Hutchison, Karen Urbanoski, Dennis Hore and Bruce Wallace
    Citation: Harm Reduction Journal 2025 22:83
  2. Among people who inject drugs and use opioids, the vast majority have reported experiencing opioid withdrawal symptoms during the past six months. People who use opioids experience significant impediments from...

    Authors: Siddhi S. Ganesh, Erin E. Gould, Rebecca P. Smeltzer, Jesse L. Goldshear, Jimi Huh, Rachel Carmen Ceasar and Ricky N. Bluthenthal
    Citation: Harm Reduction Journal 2025 22:82
  3. Syringe services programs (SSPs) reduce the risk of overdose by distributing supplies like naloxone. SSPs also support clients in meeting their basic needs via referrals to organizations providing food, housin...

    Authors: Rachel E. Gicquelais, Caitlin J. Conway, Mikaela Becker, Erika J. Bailey, Cullen Bosworth, Rebecca Miller, Katy Mijal, Emmie Curran, Bianca Barredo, Sydney Taylor, Elizabeth Salisbury-Afshar, David W. Seal, Marguerite Burns and Ryan P. Westergaard
    Citation: Harm Reduction Journal 2025 22(Suppl 1):81

    This article is part of a Supplement: Volume 22 Supplement 1

  4. This paper explores the perspectives of a group of people with lived and living expertise of unregulated drug use who worked as frontline harm reduction service providers and activists in Canada during the dua...

    Authors: Kat Gallant, Kelsey A. Speed, Alex Betsos, Brandi Abele, Matthew Bonn, Frank Crichlow, Alexandra de Kiewit, Michael Nurse, Alex Sherstobitoff, Natasha Touesnard, Karen Turner and Jade Boyd
    Citation: Harm Reduction Journal 2025 22:80
  5. Substance use remains a pressing global public health concern and has shown a marked increase in recent years. This study investigates the characteristics and risk behaviors of individuals who use substances a...

    Authors: Saeid Mirzaei, Vahid Yazdi-Feyzabadi, Mohammad Hossein Mehrolhassani, Nouzar Nakhaee and Nadia Oroomiei
    Citation: Harm Reduction Journal 2025 22:79
  6. A recent meta-analysis by Glantz et al. combined odds ratios (ORs) relating e-cigarette use (vaping) to cardiovascular disease, stroke, chronic obstructive pulmonary disease (COPD) and other endpoints. They as...

    Authors: Peter N. Lee and Konstantinos Farsalinos
    Citation: Harm Reduction Journal 2025 22:78
  7. Globally, there has been a rapid increase in the availability of online gambling. As online gambling has increased in popularity, there has been a corresponding increase in online communities that discuss gamb...

    Authors: Mark van der Maas and Jim Samuel
    Citation: Harm Reduction Journal 2025 22:77
  8. More than one million people have died from drug overdose in the United States in the past 20 years. The overdose crisis started in the late 1990s with the proliferation of overdoses involving prescription opi...

    Authors: Cerdá Magdalena, L. Allen Bennett, B. Collins Alexandra, N. Behrends Czarina, Santacatterina Michele, Jent Victoria and D. L. Marshall Brandon
    Citation: Harm Reduction Journal 2025 22(Suppl 1):76

    This article is part of a Supplement: Volume 22 Supplement 1

  9. This paper examines: (i) the acceptability of, and behavioural outcomes associated with, take-home fentanyl test strips (FTS), and (ii) support for, and preferences regarding, drug checking services among peop...

    Authors: Rachel Sutherland, Maureen Steele, Craig Rodgers, Edmund Silins, Rosie Gilliver, Amy Peacock, Monica Barratt, Nadine Ezard, Krista J. Siefried, Robert Page, Raimondo Bruno and Phillip Read
    Citation: Harm Reduction Journal 2025 22:75
  10. Death from opioid use is a growing public health concern, with stark racial and ethnic disparities. The randomized controlled trial described here aims to improve initiation and engagement in harm reduction se...

    Authors: Simon Kapler, Hira Hassan, Alexander Jeremiah, Katurah Bryant, Presto Crespo, Nesta Felix, Sónyi Elena Lopez, Antonio Morales, Sean Reeves and Ayana Jordan
    Citation: Harm Reduction Journal 2025 22(Suppl 1):74

    This article is part of a Supplement: Volume 22 Supplement 1

  11. The party setting is a dynamic social environment where the world of drug use, the role of music, and a multiplicity of social interactions all converge, often marked by the disruption of social and temporal n...

    Authors: Serena Garbolino, Marie Dos Santos, Ombline Pimond, Lionel Sayag, Nicolas Khatmi and Perrine Roux
    Citation: Harm Reduction Journal 2025 22:73
  12. Novel strategies are needed to engage people who use stimulants into the continuum of addiction care. Contingency management (CM) is the most effective intervention for stimulant use disorder and may engage no...

    Authors: Linda Peng, Erin Stack, Alexis Cooke, Bryan Hartzler, Ryan Cook, Gillian Leichtling, Christi Hildebran, Judith Leahy, Kelsey Smith Payne, Lynn Kunkel, Kim Hoffman and P. Todd Korthuis
    Citation: Harm Reduction Journal 2025 22(Suppl 1):72

    This article is part of a Supplement: Volume 22 Supplement 1

  13. Adults who smoke cigarettes can benefit from switching completely to electronic nicotine delivery systems (ENDS). Research is needed to examine longer-term switching trajectories beyond one year of follow-up.

    Authors: Arielle Selya, Sooyong Kim, Saul Shiffman and Nicholas Goldenson
    Citation: Harm Reduction Journal 2025 22:71
  14. Drawing on a qualitative case study of cannabis compassion clubs and medical dispensaries in British Columbia (Canada), the main goal of this paper is to generate insights that have the potential to advance an...

    Authors: Marilou Gagnon and Heather Hobbs
    Citation: Harm Reduction Journal 2025 22:70
  15. Although there is indisputable evidence that supervised consumption services (SCS) help to keep people safe and decrease significant harms associated with substance use, the Canadian public often holds diverge...

    Authors: Em M. Pijl, Michael Golding, Sai Krishna Gudi, Nichole Nayak, John Serieux, Christopher J. Fries, Annie Billings, Souradet Shaw, Rasheda Rabbani, Francine Laurencelle, Corey Guest and Jonny Mexico
    Citation: Harm Reduction Journal 2025 22:69
  16. In response to the ongoing drug toxicity crisis, driven by fentanyl and its analogues in the unregulated drug supply, Canada has funded several safer supply programs, which provide pharmaceutical-grade medicat...

    Authors: Frishta Nafeh, Lucas Martignetti, Carol Strike, Gillian Kolla, Matthew Bonn, Caroline Brunelle, Jade Boyd, Elaine Hyshka, Cassidy Morris, Jolene Eeuwes, Heather Hobbs, Elizabeth Haywood, Bernadette Pauly, Dan Werb and Mohammad Karamouzian
    Citation: Harm Reduction Journal 2025 22:68
  17. Despite significant efforts to address the opioid overdose crisis, Black people who use drugs (PWUD) face unabating, disproportionate increases in opioid overdose death (OOD) rates. These inequities persist in...

    Authors: Kaytryn D. Campbell, Rachel P. Winograd, Maria E. Paschke, Alex Duello and Devin E. Banks
    Citation: Harm Reduction Journal 2025 22:67
  18. Service providers at women’s harm reduction centers maintained direct contact with their clients throughout the COVID-19 pandemic, providing valuable insights into their evolving needs. This study aimed to exp...

    Authors: Azam Rahmani, Maryam Janatolmakan, Elham Rezaei and Malihe Tabarrai
    Citation: Harm Reduction Journal 2025 22:66
  19. Effective and comprehensive harm reduction strategies to mitigate gambling-related harms are needed worldwide. The development of such strategies is however resource intensive. Using existing models in multipl...

    Authors: Michael Egerer, Paula Jääskeläinen, Virve Marionneau, Riitta Matilainen, Jussi Palomäki, Eija Pietilä, Mika Tsupari, David C. Hodgins, Matthew M. Young and Sari Castrén
    Citation: Harm Reduction Journal 2025 22:65
  20. Black people in the United States face persistent and increasing inequities in addiction treatment access and drug overdose death. Incorporating people with lived experience through community based participato...

    Authors: Devin E. Banks, Maria E. Paschke, Kaytryn D. Campbell, Daje D. Bradshaw-Glenn, Rashmi Ghonasgi, Burton Barr, Arial Collins, Gerald Dennis, Keith Lofton, Alfred Long, Harriet Montgomery, Andreas Prince and Rachel P. Winograd
    Citation: Harm Reduction Journal 2025 22:64
  21. Authors: Bruce Wallace, Irene Shkolnikov, Collin Kielty, Derek Robinson, Lea Gozdzialski, Joshua Jai, Ava Margolese, Pablo Gonzalez-Nieto, Armin Saatchi, Lucas Abruzzi, Taelor Zarkovic, Chris Gill and Dennis Hore
    Citation: Harm Reduction Journal 2025 22:62

    The original article was published in Harm Reduction Journal 2025 22:28

  22. Women who inject drugs (WWIDs) belong to a group of people with high-risk behaviors for contracting HIV. In Mozambique there is still limited coverage of combined HIV prevention strategies among WWIDs. These a...

    Authors: Áuria Ribeiro Banze, Carlos Botão, Elídio Muamine, Manuel Condula, Stélio Craveirinha, Makini Boothe, Sofia Gonçalves Seabra, Isabel Craveiro and Cynthia Semá Baltazar
    Citation: Harm Reduction Journal 2025 22:61
  23. The implementation of supervised smoking facilities (SSFs) as a harm reduction intervention has public health benefits for people who inhale drugs, but there are significant knowledge gaps surrounding the pers...

    Authors: Courteney Wettemann, Jeffrey Morgan, Tara Taylor, Ardina Boll, Scott Maxwell, Lindsey Richardson, Seonaid Nolan and Jenna van Draanen
    Citation: Harm Reduction Journal 2025 22:60
  24. Permanent supportive housing (PSH) is the gold standard intervention for chronic homelessness, but PSH tenants face high risk for overdose due to a combination of individual and environmental risk factors. Lit...

    Authors: Kelly M. Doran, Allison Torsiglieri, Jocelyn Moran, Stephanie Blaufarb, Annie Y. Liu, Emily Ringrose, Cooper Urban, Lauren Velez, Patricia Hernandez, Megan A. O’Grady, Donna Shelley and Charles M. Cleland
    Citation: Harm Reduction Journal 2025 22:59
  25. Opioid-related deaths are increasing globally, and synthetic opioids intensify overdose risk. Naloxone can prevent fatalities, although too much can precipitate withdrawal and other negative reactions for the ...

    Authors: Joanne Neale, James Cassidy, Sarah Cosgrove, Ben Carter, Teodora Dascal, Clare Mackie, Nicola Metrebian and John Strang
    Citation: Harm Reduction Journal 2025 22:58
  26. Since the early days of the fight against HIV, zines have appeared to play a dual role: they encourage affected communities to voice their experiences and facilitate the exchange of information between researc...

    Authors: Marie Dos Santos, Laélia Briand-Madrid, Joachim Lévy, Jihane El Meddeb and Perrine Roux
    Citation: Harm Reduction Journal 2025 22:55
  27. Use of snus, including tobacco and nicotine pouches, is increasing in many countries. Nicotine increases blood pressure (BP) acutely, but the long-term effects of quitting the regular use of snus pouches are u...

    Authors: Peder af Geijerstam, Annelie Joelsson, Karin Rådholm and Fredrik H. Nyström
    Citation: Harm Reduction Journal 2025 22:54
  28. In 2017, Clark County, NV, implemented Public Health Vending Machines (PHVMs), an innovative approach to the dispensation of harm reduction supplies to persons who inject drugs (PWID), including sterile equipm...

    Authors: Rachel Q. Bryant, Kathleen Reich, Jessica A. Johnson, Brandon Delise, Ying Zhang, Cassius Lockett and Sean T. Allen
    Citation: Harm Reduction Journal 2025 22:52
  29. Over a million people have died from overdose since 1999, over 600,000. of which involved opioids. Treatment options that focus on overdose prevention are desperately needed and buprenorphine treatment is a fo...

    Authors: Ryan Edgerton, Peter Rebeiro, Sam MacMaster, Lisa Bell, Parul Patel, Loren Ginn, Kyra Beach, Veeraj Shah and R. Lyle Cooper
    Citation: Harm Reduction Journal 2025 22:51
  30. Understanding the hepatitis C virus (HCV) cascade of care (CoC) and factors associated with engagement is crucial for designing interventions for achieving HCV elimination. However, data on engagement in the H...

    Authors: Mehrdad Khezri, Fatemeh Tavakoli, Soheil Mehmandoost, Heidar Sharafi, Omid Zamani, Maliheh Sadat Bazrafshani, Naser Nasiri, Hossein Mirzaei, Hossein Moameri, Ali Akbar Haghdoost, Courtney McKnight, Don Des Jarlais, Mohammad Karamouzian and Hamid Sharifi
    Citation: Harm Reduction Journal 2025 22:49
  31. Reversing trends in substance use-related health inequities among Indigenous Peoples requires investments in epidemiological research anchored in community-based participatory research (CBPR) methodologies. Th...

    Authors: Sean T. Allen, Molly C. Reid, Kristin E. Schneider, Allison O’Rourke, Brady A. Garrett, Maisie Conrad, Coleman Cox, Kendra Lewis, Sierra Lewis, Lisa Wilson and Melissa Walls
    Citation: Harm Reduction Journal 2025 22:48
  32. Opioid agonist treatment (OAT) is a highly effective treatment option for people with opioid use disorder. The potent medications used create dilemmas regarding low or high thresholds to access treatment, pati...

    Authors: Johan Nordgren and Torkel Richert
    Citation: Harm Reduction Journal 2025 22:47
  33. Polysubstance use is common at electronic dance music (EDM) events and hazards associated with polysubstance use may be exacerbated when people who use drugs are unaware of the contents of their drug sample. R...

    Authors: Cianna J. Piercey, Thomas E. Schlechter, Devin Henry, Mikayla Allen-Collins, Riley Ahern, Joseph Cameron, Bradley T. Conner, Jeffrey G. Snodgrass and Hollis C. Karoly
    Citation: Harm Reduction Journal 2025 22:46
  34. The increasing implementation of harm reduction strategies such as take-home naloxone has placed people who use drugs (PWUD) in the position of overdose responders during overdose events, but the perspectives ...

    Authors: Courteney Wettemann, David L. Perlmutter, Tessa Frohe, Taylor Ryan, Grover “Will” Williams, Nathan Holland, Rachel Rourke, Robert Pitcher, Callan Elswick Fockele, Brenda Goh, Germaine Billingsley and Jenna van Draanen
    Citation: Harm Reduction Journal 2025 22:43
  35. Interventions aimed to mitigate drug-related harm include drug checking, which invloves a chemical analysis of a drug sample alongside personalized harm reduction advise. The Drug Information and Monitoring Sy...

    Authors: Stefania Schiavone, Nadia Robert Petronella Wilhelmina Hutten, Maria Bove, Maria Grazia Morgese, Luigia Trabace and Laura Alexandra Smit-Rigter
    Citation: Harm Reduction Journal 2025 22:40
  36. This project sought to contribute to healthy, safe organizational cultures within Vancouver’s hospital system healthcare system as one method to address indirect harms of the province’s drug toxicity and housi...

    Authors: Aaron Bailey, Elizabeth Bishop, Agnes T. Black, Elizabeth Dogherty, George Sedore, Marge Humchitt, John Onland, Jane Milina, Varun Bangar, Heather Mackie, Herb Varley, Tyler Byrd, Sven Black, Kristine Auigbelle and Carina Nilsson
    Citation: Harm Reduction Journal 2025 22:39
  37. As in much of the United States, there have been significant increases in overdose deaths among non-Hispanic Black and Hispanic/Latinx populations in Rhode Island over the past decade. Given the shifting dynam...

    Authors: Samantha Parker, Nya Reichley, Katie B. Biello, Jacqueline Goldman, Jane A. Buxton, Scott E. Hadland, Susan G. Sherman, Brandon D.L. Marshall and Alexandria Macmadu
    Citation: Harm Reduction Journal 2025 22:38
  38. Pharmacies often restrict access to over the counter (OTC) syringes. The objective of this study was to quantify the frequency that patients experience barriers when seeking to purchase a 10-pack of OTC syring...

    Authors: Victor Abreu, Marissa McGinnis, Savannah Justen, Phuong Y Duong, Natalea Suchy, Daniel M. Hartung and Adriane N. Irwin
    Citation: Harm Reduction Journal 2025 22:37
  39. Overdose prevention centres (OPCs) are spaces where people can consume previously obtained illicit drugs under the supervision of staff who can intervene to prevent and manage overdose. They have been provided...

    Authors: Jolie R. Keemink, Alex Stevens, Sam Shirley-Beavan, Zarnie Khadjesari and Gillian W. Shorter
    Citation: Harm Reduction Journal 2025 22:36
  40. The Australian Government introduced a major policy change tightening regulations regarding the access to nicotine containing e-cigarettes in October 2021. We assessed general practitioners’ (GPs) knowledge, a...

    Authors: Melis Selamoglu, Sowmya Malamardi, Bircan Erbas, Hester Wilson, Jamie Brown and Chris Barton
    Citation: Harm Reduction Journal 2025 22:35
  41. In many rural US Appalachian and Midwestern counties, stigma surrounding harm reduction interventions has led health professionals and policymakers to approach drug policy implementation with caution, fearing ...

    Authors: Xi Liu, Man-pui Sally Chan and Dolores Albarracín
    Citation: Harm Reduction Journal 2025 22:34